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Asbestos Mesothelioma Cancer Clinical Trials

The US Government keeps an online database, at clinicaltrials.gov, of clinical research studies for Mesothelioma cancer, but doesn't review or approve the safety and science of these trials. The website is maintained by the National Library of Medicine (NLM). The links below go to the clinical trial information on clinicaltrials.gov. Talk with your health care professional about possible risks and benefits before joining any studies.

A Prospective Cohort to Evaluate the Ability of Different Body fLuid-derived Approaches to Detect EArly-stage Cancers Among High-risk Individuals

Wed, 2 Apr 2025 00:00:00 EDT

Conditions: Risk of Breast Cancer; Risk of Gynaecological Cancer; Risk of Colorectal Cancer; Risk of Upper Gastrointestinal Cancers; Risk of Hepatic Cancers; Risk of Lung Cancer; Risk of Skin Cancers Except Basal-cell Carcinomas; Risk of Head and Neck Cancers; Risk of Mesothelioma; Risk of Kidney Cancer; Risk of Prostate Cancer; Risk of Urothelial Cancers; Risk of Endocrine Cancers; Risk of Hematologic Malignancies; Risk of Several Cancer Types; Risk of Second Malignancy in Individuals Treated for a Childhood Cancer; Risk of Neoplasia
Interventions: Diagnostic Test: biological samples
Sponsors: Gustave Roussy, Cancer Campus, Grand Paris
Not yet recruiting

Multicenter Single-Arm Study of Ivonescimab (AK112) Combined with Chemotherapy in Pretreated Pleural Mesothelioma

Tue, 25 Mar 2025 00:00:00 EDT

Conditions: Pretreated Pleural Mesothelioma
Interventions: Drug: Ivonescimab Combined With Chemotherapy
Sponsors: The First Hospital of Jilin University
Recruiting

The Diagnostic Accuracy and Clinical Value of FAPI PET in Pleural Mesothelioma

Tue, 25 Mar 2025 00:00:00 EDT

Conditions: Pleural Mesothelioma; Pleural Diseases; Cancer; FAPI; Fibroblast Activation Protein Inhibitor
Interventions: Drug: [68Ga]Ga-FAPI-46 PET/CT
Sponsors: Aalborg University Hospital
Recruiting

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients with Solid Tumors

Tue, 25 Mar 2025 00:00:00 EDT

Conditions: Solid Tumours; Sarcoma; Squamous NSCLC; Malignant Mesothelioma; HNSCC; Non Small Cell Lung Cancer; Head and Neck Squamous Cell Carcinoma
Interventions: Drug: OKN4395; Combination Product: Pembrolizumab; Other: Fasting; Other: Fed
Sponsors: Epkin; Precision For Medicine
Recruiting

Genetic Susceptibility in MAlignant Pleural Mesothelioma: Clinical Implication of GermliNE VariaTionS

Tue, 25 Mar 2025 00:00:00 EDT

Conditions: Mesothelioma, Malignant Pleural
Sponsors: Fondazione IRCCS Policlinico San Matteo di Pavia; Istituti Clinici Scientifici Maugeri di Pavia
Recruiting

Evaluating Ivonescimab As a Potential Treatment for Pleural Mesothelioma Patients Whose Cancer Has Returned After Previous Immunotherapy and Chemotherapy

Tue, 25 Mar 2025 00:00:00 EDT

Conditions: Pleural Mesotheliomas
Interventions: Drug: Ivonescimab
Sponsors: Intergroupe Francophone de Cancerologie Thoracique; Summit Therapeutics
Not yet recruiting

CT-95 in Advanced Cancers Associated with Mesothelin Expression

Tue, 25 Mar 2025 00:00:00 EDT

Conditions: Mesothelin-Expressing Tumors; Epithelial Ovarian Cancer; Malignant Pleural Mesothelioma, Advanced; Malignant Peritoneal Mesothelioma, Advanced; Pancreatic Adenocarcinoma Advanced or Metastatic; Lung Adenocarcinoma Metastatic; Cholangiocarcinoma Advanced; Cholangiocarcinoma Non-resectable; Mesothelin-expressing Advanced Cancers; Mesothelin-positive Advanced Malignant Solid Tumors
Interventions: Drug: CT-95
Sponsors: Context Therapeutics Inc.
Recruiting

A Long-Term Follow-Up Study of Participants Treated with A2 Biotherapeutics (A2 Bio) Gene Therapy (GT) Products

Tue, 25 Mar 2025 00:00:00 EDT

Conditions: Solid Tumor Cancer; Solid Tumor, Unspecified, Adult; Colorectal Carcinoma; Colorectal Carcinoma (CRC); Non Small Cell Lung Cancer; Small Cell Lung Cancer ( SCLC ); Pancreatic Cancer; NSCLC; Mesothelioma; Ovarian Cancer; Ovarian Carcinoma; Head and Neck (HNSCC); Head and Neck Cancer; Renal Cell Carcinoma (Kidney Cancer); Triple Negative Breast Cancer (TNBC)
Interventions: Other: No additional intervention administered in this long term follow-up study
Sponsors: A2 Biotherapeutics Inc.
Not yet recruiting

IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE Cancers

Tue, 25 Mar 2025 00:00:00 EDT

Conditions: Peritoneal Mesothelioma; Gestational Trophoblastic Tumor; Thymoma and Thymic Carcinoma; Anaplastic Thyroid Carcinomas; Gastroenteropancreatic Neuroendocrine Tumor; Carcinoid Tumor
Interventions: Drug: DOMVANALIMAB + ZIMBERELIMAB; Drug: DOMVANALIMAB + ZIMBERELIMAB + FOLFOX-4
Sponsors: Hospices Civils de Lyon
Not yet recruiting

Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma

Tue, 25 Mar 2025 00:00:00 EDT

Conditions: Mesothelioma; Neoplasms; Stomach Neoplasms; Pancreatic Neoplasms; Ovarian Neoplasms; Lung Neoplasms; Thymus Neoplasms; Colonic Neoplasms
Interventions: Device: mesothelin expression testing; Biological: TNhYP217 CAR T Cells; Drug: fludarabine; Drug: cyclophosphamide
Sponsors: National Cancer Institute (NCI)
Not yet recruiting